PARP Targeted Alpha-Particle Therapy Enhances Response to PD-1 Immune-Checkpoint Blockade in a Syngeneic Mouse Model of Glioblastoma

We’ve got beforehand demonstrated potent antitumor results of PARP focused alpha-therapy with astatine-211-MM4 ([211At]MM4) in neuroblastoma preclinical fashions, though differential sensitivity suggests it’s unlikely to be healing as a single-agent in all tumor sorts. Alpha-particle induced DNA injury can elicit an immune response that leads to T-cell activation towards tumor cells; nevertheless, tumor cells can

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