Non-radioactive and sensitive tracking of neutrophils towards inflammation using antibody functionalized magnetic particle imaging tracers
White blood cells (WBCs) are a key part of the mammalian immune system and play a necessary position in surveillance, protection, and adaptation towards overseas pathogens. Aside from their roles within the lively fight of an infection and the event of adaptive immunity, immune cells are additionally concerned in tumor growth and metastasis. Antibody-based therapeutics have been developed to control (i.e. selectively activate or inhibit immune perform) and harness immune cells to struggle malignancy.
Alternatively, non-invasive monitoring of WBC distribution can diagnose irritation, an infection, fevers of unknown origin (FUOs), and most cancers. Magnetic Particle Imaging (MPI) is a non-invasive, non-radioactive, and delicate medical imaging approach that makes use of secure superparamagnetic iron oxide nanoparticles (SPIOs) as tracers. MPI has beforehand been proven to trace therapeutic stem cells for over 87 days with a ~200 cell detection restrict. Within the present work, we utilized antibody-conjugated SPIOs particular to neutrophils for in situ labeling, and non-invasive and radiation-free monitoring of those inflammatory cells to websites of an infection and irritation in an in vivo murine mannequin of lipopolysaccharide-induced myositis. MPI confirmed delicate detection of irritation with a contrast-to-noise ratio of ~8-13.
Technogenic magnetic particles from metal metallurgy and iron mining in topsoil: Indicative attribute by magnetic parameters and Mössbauer spectra
Technogenic magnetic particles (TMPs), produced throughout varied industrial processes, are launched into the ambiance as mud and get deposited on the encircling topsoil. The mineralogical and structural variations of TMPs produced in several technological processes needs to be mirrored of their magnetic properties and subsequently needs to be indicative for industrial air pollution sources.
The objective of this examine was to characterize the TMPs by novel methodological strategy, primarily based on mixture of magnetic strategies and Mössbauer spectroscopy to point parameters which can be discriminative sufficient for use as environmental indicators for iron metallurgy, metal manufacturing, and iron mining. We collected the topsoil samples within the neighborhood of four European iron- and steelworks, positioned in three totally different international locations (Poland, Norway, and Czech Republic) and working for minimal 40 years.
We sampled additionally topsoil near the opencast iron mine, iron ore dressing plant, and over strongly magnetic pure background. Evaluation of the hyperfine parameters of the Mössbauer spectra revealed that TMPs are “magnetite-like” minerals with low stoichiometry. It’s indicated by ratio of iron ions contributions in B websites (octahedral) and A websites (tetrahedral) in magnetite spinel construction, which is far decrease than 2.0 (theoretical worth for stoichiometric magnetite).
The attribute function of TMPs collected from the neighborhood of outdated metallurgical vegetation (>180 years) was the excessive contribution of floor elements in all probability associated to the floor oxidation/maghemitization. We discovered that, TMPs could be simply differentiated from geogenic magnetite primarily based on their magnetic parameters.
The TMP produced by the iron and metal metallurgy had comparatively slim ranges of magnetic parameters (saturation ratio Mrs/Ms, <0.15, coercivity ratio Bcr/Bc 2.5-6.Zero and saturation to susceptibility ratio Mrs/χ 3.5-15). These magnetic parameters could also be indicative for TMPs emitted by these air pollution sources and useful within the examine of historic air pollution sources in topsoil in city and post-industrial areas.
Mass dose charges of particle-bound natural pollution within the human respiratory tract: Implications for inhalation publicity and danger estimations
Thus far, little is thought in regards to the efficient doses of airborne particulate matter (PM) and PM-bound hazardous natural elements to the human respiratory tract (HRT). Within the mild of this, right here we offer particle mass dose charges (dose per hour of publicity) of PM and a collection of PM-bound hazardous natural compounds within the HRT for 2 inhabitants age teams (adults & youngsters).

Extra particularly, the mass dose charges of PM and PM-bound polycyclic fragrant hydrocarbons (PAHs), nitrated-PAH (NPAHs), polychlorinated biphenyls (PCBs), organochlorine pesticides (OCPs) and polybrominated diphenyl ethers (PBDEs) had been estimated at two city websites utilizing a a number of path particle dosimetry mannequin. We discover that, typically, the whole mass doses are following related variations throughout websites and seasons as their ambient whole concentrations, nevertheless their distribution within the HRT is a perform of the particle measurement distributions and the physiological parameters of every age group.
Extra particularly, nearly all of the deposited mass of PM and all of the chemical elements investigated was amassed within the higher airways as a substitute of the lungs. We additional present that youngsters, resulting from their totally different physiology, are extra prone and obtain bigger fraction of the whole mass doses within the deepest components of the lungs in comparison with the adults’ group.
DiagNano Silica-Coated Gold Nanoparticles, 10 nm, 100 OD |
CG-10-100 |
Creative Diagnostics |
0.25mL |
EUR 926.4 |
DiagNano Silica-Coated Gold Nanoparticles, 20 nm, 100 OD |
CG-20-100 |
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0.25mL |
EUR 926.4 |
DiagNano Silica-Coated Gold Nanoparticles, 5 nm, 100 OD |
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0.25mL |
EUR 1088.4 |
DiagNano Streptavidin Conjugated Gold Nanoparticles, 150 nm |
GCS-150 |
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1mL |
EUR 1300.8 |
DiagNano Streptavidin Conjugated Gold Nanoparticles, 200 nm |
GCS-200 |
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1mL |
EUR 1300.8 |
DiagNano Anti-Methadone Conjugated Gold Nanoparticles |
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5 mL |
EUR 1251.6 |
DiagNano Anti-Oxycodone Conjugated Gold Nanoparticles |
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5 mL |
EUR 1275.6 |
DiagNano Anti-Beta FSH Conjugated Gold Nanoparticles |
ACG-BFSH01 |
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5 mL |
EUR 1251.6 |
DiagNano Anti-Beta TSH Conjugated Gold Nanoparticles |
ACG-BTSH01 |
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5 mL |
EUR 1376.4 |
DiagNano rHIV gp120/gp41 Conjugated Gold Nanoparticles |
ACG-HIV04 |
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5 mL |
EUR 1251.6 |
DiagNano Anti-H. pylori Conjugated Gold Nanoparticles |
ACG-HPY01 |
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5 mL |
EUR 1300.8 |
DiagNano Anti-K2 (Spice) Conjugated Gold Nanoparticles |
ACG-SK201 |
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5 mL |
EUR 1275.6 |
DiagNano Anti-Alpha hCG Conjugated Gold Nanoparticles |
ACG-ACG01 |
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5 mL |
EUR 1189.2 |
DiagNano Anti-Human IgM Conjugated Gold Nanoparticles |
ACG-HIM01 |
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5 mL |
EUR 1300.8 |
DiagNano Anti-Amphetamine Conjugated Gold Nanoparticles |
ACG-AMP01 |
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5 mL |
EUR 1201.2 |
DiagNano Anti-Barbiturate Conjugated Gold Nanoparticles |
ACG-BAR01 |
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5 mL |
EUR 1251.6 |
DiagNano Anti-Benzodiazepine Conjugated Gold Nanoparticles |
ACG-BZO01 |
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5 mL |
EUR 1251.6 |
DiagNano Recombinant Syphilis Conjugated Gold Nanoparticles |
ACG-RSY04 |
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5 mL |
EUR 1275.6 |
DiagNano Anti-Malaria pLDH Conjugated Gold Nanoparticles |
ACG-MAL02 |
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5 mL |
EUR 1251.6 |
DiagNano Anti-Methamphetamine Conjugated Gold Nanoparticles |
ACG-MET01 |
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5 mL |
EUR 1201.2 |
DiagNano Silica-Coated PEGylated Gold Nanoparticles, 10 nm |
PG-10 |
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10mL |
EUR 862.8 |
DiagNano Silica-Coated PEGylated Gold Nanoparticles, 20 nm |
PG-20 |
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10mL |
EUR 862.8 |
DiagNano Rabbit Anti-Ketamine Conjugated Gold Nanoparticles |
ACG-KET01 |
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5 mL |
EUR 1376.4 |
DiagNano Silica-Coated PEGylated Gold Nanoparticles, 10 nm, 100 OD |
PG-10-100 |
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0.25mL |
EUR 1101.6 |
DiagNano Silica-Coated PEGylated Gold Nanoparticles, 20 nm, 100 OD |
PG-20-100 |
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0.25mL |
EUR 1101.6 |
DiagNano Silica-Coated PEGylated Gold Nanoparticles, 5 nm, 100 OD |
PG-5-100 |
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0.25mL |
EUR 1275.6 |
DiagNano Goat Anti-Alpha hCG Conjugated Gold Nanoparticles |
ACG-ACG02 |
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5 mL |
EUR 1201.2 |
DiagNano Goat Anti-Human IgA Conjugated Gold Nanoparticles |
ACG-HIA01 |
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5 mL |
EUR 1251.6 |
DiagNano Goat Anti-Human IgM Conjugated Gold Nanoparticles |
ACG-HIM02 |
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5 mL |
EUR 1275.6 |
DiagNano Anti-Human Hemoglobin Conjugated Gold Nanoparticles |
ACG-HHB01 |
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5 mL |
EUR 1275.6 |
DiagNano Anti-Phencyclidine (PCP) Conjugated Gold Nanoparticles |
ACG-PCP01 |
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5 mL |
EUR 1251.6 |
DiagNano Anti-Propoxyphene (PPX) Conjugated Gold Nanoparticles |
ACG-PPX01 |
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5 mL |
EUR 1251.6 |
DiagNano Hepatitis C Virus (HCV) Conjugated Gold Nanoparticles |
ACG-HCV01 |
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5 mL |
EUR 1300.8 |
DiagNano Anti-Troponin I (cTNI) Conjugated Gold Nanoparticles |
ACG-TNI01 |
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5 mL |
EUR 1450.8 |
DiagNano Cancer Antigen 125 (CA 125) Conjugated Gold Nanoparticles |
ACG-CAG01 |
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5 mL |
EUR 1450.8 |
DiagNano Anti-Influenza A Virus Conjugated Gold Nanoparticles |
ACG-IAV01 |
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5 mL |
EUR 1251.6 |
DiagNano Biotin Bovine Serum Albumin Conjugated Gold Nanoparticles |
ACG-BSA01 |
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5 mL |
EUR 1189.2 |
DiagNano Anti-Human Hemoglobin (A1c) Conjugated Gold Nanoparticles |
ACG-HHB02 |
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5 mL |
EUR 1251.6 |
DiagNano Anti-Malaria (HRPII-IgG) Conjugated Gold Nanoparticles |
ACG-MAL01 |
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5 mL |
EUR 1300.8 |
DiagNano Recombinant Syphilis (17 kDa) Conjugated Gold Nanoparticles |
ACG-RSY01 |
Creative Diagnostics |
5 mL |
EUR 1275.6 |
DiagNano Recombinant Syphilis (15 kDa) Conjugated Gold Nanoparticles |
ACG-RSY02 |
Creative Diagnostics |
5 mL |
EUR 1275.6 |
DiagNano Recombinant Syphilis (47 kDa) Conjugated Gold Nanoparticles |
ACG-RSY03 |
Creative Diagnostics |
5 mL |
EUR 1275.6 |
DiagNano Anti-Benzoylecgonine (cocaine) Conjugated Gold Nanoparticles |
ACG-BEN01 |
Creative Diagnostics |
5 mL |
EUR 1300.8 |
DiagNano Anti-Alpha Fetoprotein (AFP) Conjugated Gold Nanoparticles |
ACG-AFP01 |
Creative Diagnostics |
5 mL |
EUR 1525.2 |
DiagNano Anti-Tetrahydrocannabinol (THC) Conjugated Gold Nanoparticles |
ACG-THC01 |
Creative Diagnostics |
5 mL |
EUR 1251.6 |
DiagNano Fluorophore Labeled Gold Nanoparticles, 10 nm, Cellular Uptake |
GFL-10-CU |
Creative Diagnostics |
1mL |
EUR 1638 |
DiagNano Fluorophore Labeled Gold Nanoparticles, 15 nm, Cellular Uptake |
GFL-15-CU |
Creative Diagnostics |
1mL |
EUR 1638 |
DiagNano Fluorophore Labeled Gold Nanoparticles, 20 nm, Cellular Uptake |
GFL-20-CU |
Creative Diagnostics |
1mL |
EUR 1638 |
DiagNano Fluorophore Labeled Gold Nanoparticles, 25 nm, Cellular Uptake |
GFL-25-CU |
Creative Diagnostics |
1mL |
EUR 1638 |
DiagNano Fluorophore Labeled Gold Nanoparticles, 30 nm, Cellular Uptake |
GFL-30-CU |
Creative Diagnostics |
1mL |
EUR 1638 |
DiagNano Fluorophore Labeled Gold Nanoparticles, 35 nm, Cellular Uptake |
GFL-35-CU |
Creative Diagnostics |
1mL |
EUR 1638 |
DiagNano Fluorophore Labeled Gold Nanoparticles, 40 nm, Cellular Uptake |
GFL-40-CU |
Creative Diagnostics |
1mL |
EUR 1638 |
DiagNano Fluorophore Labeled Gold Nanoparticles, 45 nm, Cellular Uptake |
GFL-45-CU |
Creative Diagnostics |
1mL |
EUR 1638 |
DiagNano Fluorophore Labeled Gold Nanoparticles, 50 nm, Cellular Uptake |
GFL-50-CU |
Creative Diagnostics |
1mL |
EUR 1638 |
DiagNano Anti-CRP (C-Reactive Protein) Conjugated Gold Nanoparticles |
ACG-CRP01 |
Creative Diagnostics |
5 mL |
EUR 1275.6 |
DiagNano Goat Anti-Alpha Fetoprotein (AFP) Conjugated Gold Nanoparticles |
ACG-AFP02 |
Creative Diagnostics |
5 mL |
EUR 1376.4 |
DiagNano Anti-Beta Luteinizing Hormone (LH) Conjugated Gold Nanoparticles |
ACG-BLH01 |
Creative Diagnostics |
5 mL |
EUR 1189.2 |
DiagNano Anti-Carcinoembryonic Antigen (CEA) Conjugated Gold Nanoparticles |
ACG-CEA01 |
Creative Diagnostics |
5 mL |
EUR 1251.6 |
DiagNano Anti-Tricyclic Antidepressant (TCA) Conjugated Gold Nanoparticles |
ACG-TCA01 |
Creative Diagnostics |
5 mL |
EUR 1275.6 |
DiagNano Anti-Alpha Luteinizing Hormone (LH) Conjugated Gold Nanoparticles |
ACG-ALH01 |
Creative Diagnostics |
5 mL |
EUR 1251.6 |
DiagNano Anti-Prostate Specific Antigen (PSA) Conjugated Gold Nanoparticles |
ACG-PSA01 |
Creative Diagnostics |
5 mL |
EUR 1251.6 |
DiagNano Goat Anti-Human IgM Fc (5u specific) Conjugated Gold Nanoparticles |
ACG-HIM03 |
Creative Diagnostics |
5 mL |
EUR 1300.8 |
DiagNano Goat Anti-Alpha Luteinizing Hormone (LH) Conjugated Gold Nanoparticles |
ACG-ALH02 |
Creative Diagnostics |
5 mL |
EUR 1076.4 |
DiagNano Amine Upconverting Nanoparticles, 365 nm/475 nm |
DNL-F006 |
Creative Diagnostics |
10 mg |
EUR 1138.8 |
DiagNano Amine Upconverting Nanoparticles, 545 nm/660 nm |
DNL-F008 |
Creative Diagnostics |
10 mg |
EUR 1138.8 |
DiagNano Gold Nanoparticle Passive Conjugation Kit, TEM |
GPK-TEM |
Creative Diagnostics |
1 kit |
EUR 976.8 |
DiagNano Gold Nanoparticle Passive Conjugation Kit, 100 nm |
GPK-100 |
Creative Diagnostics |
1 kit |
EUR 858 |
Absolute Mag BSA Magnetic Dextran Nanoparticles, 100 nm |
WHM-G077 |
Creative Diagnostics |
5 mL |
EUR 770.4 |
DiagNano Green Fluorescent Silica Nanoparticles, 100 nm |
DNG-L015 |
Creative Diagnostics |
10 mL |
EUR 752.4 |
DiagPoly Streptavidin Polystyrene Nanoparticles, 100 nm |
DNG-P076 |
Creative Diagnostics |
1 mL |
EUR 951.6 |
DiagPoly Streptavidin Polystyrene Nanoparticles, 200 nm |
DNG-P077 |
Creative Diagnostics |
1 mL |
EUR 951.6 |
DiagNano PEG-NH2 Upconverting Nanoparticles, 365 nm/475 nm |
DNL-H009 |
Creative Diagnostics |
10 mg |
EUR 1138.8 |
DiagNano PEG-NH2 Upconverting Nanoparticles, 545 nm/660 nm |
DNL-H011 |
Creative Diagnostics |
10 mg |
EUR 1138.8 |
Absolute Mag Streptavidin Magnetic Nanoparticles, 130 nm |
WHM-B005 |
Creative Diagnostics |
100 μL, 1 mL |
Ask for price |
DiagNano PEG Coated Upconverting Nanoparticles, 365 nm/475 nm |
DNL-F001 |
Creative Diagnostics |
10 mg |
EUR 1326 |
DiagNano PEG Coated Upconverting Nanoparticles, 545 nm/660 nm |
DNL-F003 |
Creative Diagnostics |
10 mg |
EUR 1326 |
DiagNano PEG-COOH Upconverting Nanoparticles, 365 nm/475 nm |
DNL-H001 |
Creative Diagnostics |
10 mg |
EUR 1138.8 |
DiagNano PEG-COOH Upconverting Nanoparticles, 545 nm/660 nm |
DNL-H003 |
Creative Diagnostics |
10 mg |
EUR 1138.8 |
Absolute Mag Plain Magnetic Dextran Nanoparticles, 100 nm |
WHM-G071 |
Creative Diagnostics |
10 mL |
EUR 853.2 |
Absolute Mag Amine Magnetic Dextran Nanoparticles, 100 nm |
WHM-G072 |
Creative Diagnostics |
5 mL |
EUR 602.4 |
Absolute Mag Plain Magnetic Dextran Nanoparticles, 130 nm |
WHM-G081 |
Creative Diagnostics |
10 mL |
EUR 874.8 |
Absolute Mag Amine Magnetic Dextran Nanoparticles, 130 nm |
WHM-G082 |
Creative Diagnostics |
5 mL |
EUR 686.4 |
Absolute Mag Avidin Magnetic Dextran Nanoparticles, 100 nm |
WHM-G074 |
Creative Diagnostics |
2 mL |
EUR 770.4 |
Absolute Mag Biotin Magnetic Dextran Nanoparticles, 100 nm |
WHM-G078 |
Creative Diagnostics |
2 mL |
EUR 770.4 |
Absolute Mag Avidin Magnetic Dextran Nanoparticles, 250 nm |
WHM-M069 |
Creative Diagnostics |
2 mL |
EUR 706.8 |
Absolute Mag Avidin Magnetic Dextran Nanoparticles, 500 nm |
WHM-M070 |
Creative Diagnostics |
2 mL |
EUR 770.4 |
Absolute Mag Human Anti-PE Magnetic Nanoparticles, 130 nm |
WHM-B003 |
Creative Diagnostics |
100 μL, 1 mL |
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Absolute Mag Mouse Anit-PE Magnetic Nanoparticles, 130 nm |
WHM-B012 |
Creative Diagnostics |
100 μL, 1 mL |
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DiagNano Red Fluorescent, Amine Silica Nanoparticles, 100 nm |
DNG-L048 |
Creative Diagnostics |
10 mL |
EUR 820.8 |
Absolute Mag Human Anti-APC Magnetic Nanoparticles, 130 nm |
WHM-B004 |
Creative Diagnostics |
100 μL, 1 mL |
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Absolute Mag Mouse Anit-CD4 Magnetic Nanoparticles, 130 nm |
WHM-B008 |
Creative Diagnostics |
20 tests, 200 tests |
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Absolute Mag Mouse Anit-APC Magnetic Nanoparticles, 130 nm |
WHM-B013 |
Creative Diagnostics |
100 μL, 1 mL |
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Absolute Mag Anti-Human CD8 Magnetic Nanoparticles, 130 nm |
WHM-X001 |
Creative Diagnostics |
10 tests, 100 tests |
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Absolute Mag Ni-NTA Magnetic Dextran Nanoparticles, 250 nm |
WHM-X058 |
Creative Diagnostics |
10 mL |
EUR 812.4 |
DiagNano Gold Nanoparticle Passive Conjugation Kit, Dot-blot |
GPK-DB |
Creative Diagnostics |
1 kit |
EUR 976.8 |
DiagNano Oil Dispersible Upconverting Nanoparticles, 804 nm |
DNL-B005 |
Creative Diagnostics |
10 mg |
EUR 1014 |
Absolute Mag Carboxyl Magnetic Dextran Nanoparticles, 100 nm |
WHM-G073 |
Creative Diagnostics |
5 mL |
EUR 608.4 |
Absolute Mag Carboxyl Magnetic Dextran Nanoparticles, 130 nm |
WHM-G083 |
Creative Diagnostics |
10 mL |
EUR 1000.8 |
Absolute Mag Mouse Anit-CD8a Magnetic Nanoparticles, 130 nm |
WHM-B006 |
Creative Diagnostics |
20 tests, 200 tests |
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Absolute Mag Mouse Anit-CD45 Magnetic Nanoparticles, 130 nm |
WHM-B007 |
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20 tests, 200 tests |
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Absolute Mag Human Anit-CD45 Magnetic Nanoparticles, 130 nm |
WHM-B014 |
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20 tests, 200 tests |
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Absolute Mag Human Anit-CD41 Magnetic Nanoparticles, 130 nm |
WHM-B017 |
Creative Diagnostics |
10 tests, 100 tests |
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Absolute Mag Human Anit-CD14 Magnetic Nanoparticles, 130 nm |
WHM-B018 |
Creative Diagnostics |
20 tests, 200 tests |
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Absolute Mag PEG-NH2 Magnetic Dextran Nanoparticles, 100 nm |
WHM-G079 |
Creative Diagnostics |
5 mL |
EUR 670.8 |
DiagNano Green Fluorescent, Amine Silica Nanoparticles, 100 nm |
DNG-L047 |
Creative Diagnostics |
10 mL |
EUR 814.8 |
DiagNano Gold Nanoparticle Medium Covalent Conjugation Kit, 100 nm |
GCK-M-100 |
Creative Diagnostics |
1 kit |
EUR 908.4 |
DiagNano Gold Nanoparticle Medium Covalent Conjugation Kit, 15 nm |
GCK-M-15 |
Creative Diagnostics |
1 kit |
EUR 908.4 |
DiagNano Gold Nanoparticle Medium Covalent Conjugation Kit, 20 nm |
GCK-M-20 |
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1 kit |
EUR 908.4 |
DiagNano Gold Nanoparticle Medium Covalent Conjugation Kit, 30 nm |
GCK-M-30 |
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1 kit |
EUR 908.4 |
DiagNano Gold Nanoparticle Medium Covalent Conjugation Kit, 40 nm |
GCK-M-40 |
Creative Diagnostics |
1 kit |
EUR 908.4 |
DiagNano Gold Nanoparticle Medium Covalent Conjugation Kit, 5 nm |
GCK-M-5 |
Creative Diagnostics |
1 kit |
EUR 908.4 |
DiagNano Gold Nanoparticle Medium Covalent Conjugation Kit, 50 nm |
GCK-M-50 |
Creative Diagnostics |
1 kit |
EUR 908.4 |
Evaluating the standard methodology for estimating the inhalation danger, which relies on the ambient focus of pollution, and a modified model utilizing the mass dose within the HRT, we discover that the previous might overestimate the reported dangers. The outcomes introduced right here present a novel dataset composed by beforehand undetermined doses of hazardous airborne particulate natural elements within the HRT and show that different well being danger estimation approaches might seize some variabilities which can be historically neglected.
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